Fig. 7From: Anticancer properties and enhancement of therapeutic potential of cisplatin by leaf extract of Zanthoxylum armatum DC.Speculative mechanism of ZALE mediated cell death. ZALE induced DNA damage and ERK activation. Activation of ERK released AIF that lead to apoptosis in a caspase independent manner. Alternatively, sequential treatment of ZALE with chemotherapeutic drugs enhanced caspase activation, leading to caspase dependent apoptosisBack to article page