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Fig. 6 | Biological Research

Fig. 6

From: Anticancer properties and enhancement of therapeutic potential of cisplatin by leaf extract of Zanthoxylum armatum DC.

Fig. 6

ZALE enhanced chemotherapeutic drugs induced apoptosis. a Screening of medicinal plants that increased the cisplatin induced cytotoxicity. HeLa cells were pretreated with the plant extracts (15 μg/ml) for 16 h before treatment with cisplatin (3 μM) for 72 h. Viable cells were measured. b Immunoblot showing that ZALE pretreatment increased cisplatin.induced caspase activation HeLa cells were treated as denoted and the cells were lysed and immunoblotted with caspase 3 antibody. c Sequential treatment of ZALE with chemotherapeutic drugs show synergistic apoptosis. HeLa cells were pre-treated with low dose (15 μg/ml) of ZALE for 16 h and then treated with 100 ng/ml of mitomycin C (MMC) or 10 ng/ml of camptothecin (CPT) or cisplatin (3 μM) for 72 h. Viable cells were measured as described else where asterisk indicates Q value more than 1.15 according to Jin’s formula

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