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Fig. 2 | Biological Research

Fig. 2

From: Suppression of miR-181a attenuates H2O2-induced death of mesenchymal stem cells by maintaining hexokinase II expression

Fig. 2

MicroRNA-181a targets HKII and increased by H2O2. a Candidate HKII-targeting miRNAs were selected based on miRNA-target prediction databases (TargetScan and miRWalk). b Effect of six candidate miRNAs on the expression of HKII was examined by western blot. *p < 0.05 compared to Control. c Luciferase assay using 3′UTR of HKII was performed to confirm the interaction between miR-181a and HKII. *p < 0.05 compared to Control [miR (−)]. NC negative control miRNA. d Time dependent expression changes of miR-181 in MSCs exposed to H2O2. *p < 0.05 compared to Control. The quantitative data were expressed as the mean ± s.e.m of at least three independent experiments.

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