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Table 2 Functional and locational gene product categorization of the interactome network of genes whose deletion provokes resistance to Sortin2 in S. cerevisiae

From: Sortin2 enhances endocytic trafficking towards the vacuole in Saccharomyces cerevisiae

 

Representation on dataset

Sortin2 interactome (%)

Genome (%)

p-value

Enrichment in dataset (fold)

Functional category

Cell fate

15.5

4.5

1.77E−13

3.5

Cell type differentiation

24.2

7.4

1.90E−19

3.3

Cell cycle and DNA processing

39.1

16.5

2.32E−20

2.4

Cellular communication/signal transduction mechanism

9.1

3.8

4.38E−05

2.4

Biogenesis of cellular components

31.1

14.0

6.35E−14

2.2

Cell rescue, defense and virulence

19.2

9.0

6.05E−08

2.1

Protein fate (folding, modification, destination)

38.0

18.8

1.55E−14

2.0

Interaction with the environment

15.2

7.6

7.12E−06

2.0

Protein with binding function or cofactor requirement (structural or catalytic)

27.5

17.1

6.42E−06

1.6

Cellular transport, transport facilities and transport routes

25.3

16.9

1.82E−04

1.5

Transcription

23.5

17.5

5.99E−03

1.3

Locational category

Cytoskeleton

13.0

3.3

6.31E−13

3.9

 Actin cytoskeleton

8.0

0.9

3.55E−16

9.0

Punctate composite

6.2

2.3

1.63E−04

2.7

Transport vesicles

5.8

2.3

5.50E−04

2.5

Cytoplasm

61.2

46.3

2.91E−07

1.3

Nucleus

46.3

34.8

3.46E−05

1.3

  1. Category representation of the abundance within the Sortin2-resistance interactome network (dataset 273 genes) and the S. cerevisiae genome (6131 genes). The p-value was calculated using the hypergeometric distribution as the statistical test. p < 0.005 was considered as significant.