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Table 2 Functional and locational gene product categorization of the interactome network of genes whose deletion provokes resistance to Sortin2 in S. cerevisiae

From: Sortin2 enhances endocytic trafficking towards the vacuole in Saccharomyces cerevisiae

  Representation on dataset
Sortin2 interactome (%) Genome (%) p-value Enrichment in dataset (fold)
Functional category
Cell fate 15.5 4.5 1.77E−13 3.5
Cell type differentiation 24.2 7.4 1.90E−19 3.3
Cell cycle and DNA processing 39.1 16.5 2.32E−20 2.4
Cellular communication/signal transduction mechanism 9.1 3.8 4.38E−05 2.4
Biogenesis of cellular components 31.1 14.0 6.35E−14 2.2
Cell rescue, defense and virulence 19.2 9.0 6.05E−08 2.1
Protein fate (folding, modification, destination) 38.0 18.8 1.55E−14 2.0
Interaction with the environment 15.2 7.6 7.12E−06 2.0
Protein with binding function or cofactor requirement (structural or catalytic) 27.5 17.1 6.42E−06 1.6
Cellular transport, transport facilities and transport routes 25.3 16.9 1.82E−04 1.5
Transcription 23.5 17.5 5.99E−03 1.3
Locational category
Cytoskeleton 13.0 3.3 6.31E−13 3.9
 Actin cytoskeleton 8.0 0.9 3.55E−16 9.0
Punctate composite 6.2 2.3 1.63E−04 2.7
Transport vesicles 5.8 2.3 5.50E−04 2.5
Cytoplasm 61.2 46.3 2.91E−07 1.3
Nucleus 46.3 34.8 3.46E−05 1.3
  1. Category representation of the abundance within the Sortin2-resistance interactome network (dataset 273 genes) and the S. cerevisiae genome (6131 genes). The p-value was calculated using the hypergeometric distribution as the statistical test. p < 0.005 was considered as significant.