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Table 1 Gene ontology (GO) of genes whose deletion provokes resistance to Sortin2 in S. cerevisiae

From: Sortin2 enhances endocytic trafficking towards the vacuole in Saccharomyces cerevisiae

Gene/ORF

GO function

GO process

GO component

References

SLA1

YBL007C

Protein binding, bridging1

Ubiquitin binding2

Actin binding3

Cytoskeletal protein binding4

Identical protein binding4

Actin cortical patch assembly5

Endocytosis6

Fungal-type cell wall organization5

Actin cortical patch7

Cell cortex1

Nucleus8

Mating projection tip9

Cytoskeleton3

Endosome membrane3

Plasma membrane3

1Warren et al. [17]

2Stamenova et al. [18]

3UniProt-GOA [19]

4DDB et al. [20]

5Pruyne and Bretscher [21]

6Howard et al. [22]

7Ayscough et al. [23]

8Gardiner et al. [24]

9Narayanaswamy et al. [25]

CLC1

YGR167W

Structural molecule activity1

Calmodulin binding2

Structural molecule activity3

Endocytosis4

Vesicle-mediated Transport1,3

Intracellular protein transport3

Clathrin vesicle coat1

Clathrin coat of coated pit3

Clathrin coat of trans-Golgi network vesicle3

1Pishvaee et al. [26]

2UniProt-GOA [19]

3DDB et al. [20]

4Newpher and Lemmon [27]

MET18

YIL128W

Binding5

Methionine metabolic process1

Nucleotide-excision repair2

Transcription from RNA polymerase II promoter3

DNA repair6

Response to DNA damage stimulus6

Transcription, DNA-dependent6

Cytoplasm4

Nucleus6

1Masselot and De Robichon-Szulmajster [28]

2Kou et al. [29]

3Lauder et al. [30]

4Huh et al. [31]

5DDB et al. [20]

6UniProt-GOA [19]

DFG10

YIL049W

3-Oxo-5-alpha-steroid 4-dehydrogenase activity1

Oxidoreductase activity, acting on the CH–CH group of donors5

Dolichol biosynthetic process1

Pseudohyphal growth2

Lipid metabolic process5

Integral to membrane3,4,5

Endoplasmic reticulum membrane4

1Cantagrel et al. [32]

2Mosch and Fink [33]

3De Hertogh et al. [34]

4UniProt-GOA [19]

5DDB et al. [20]

DPL1

YDR294C

Sphinganine-1-phosphate aldolase activity1

Carboxy-lyase activity6

Pyridoxal phosphate binding6

Calcium-mediated signaling2

Cellular response to starvation3

Sphingolipid metabolic process1

Carboxylic acid metabolic process6

Endoplasmic reticulum4,5

1Saba et al. [35]

2Birchwood et al. [36]

3Gottlieb et al. [37]

4Mukhopadhyay et al. [38]

5Huh et al. [31]

6DDB et al. [20]

YJL175W

YJL175W

Unknown

Unknown

Integral to membrane1

1De Hertogh et al. [34]

  1. Biological process, molecular function and cellular component GO are shown for each ORF.