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Table 3 Effects of incubation with karanjin for 72 h on cell apoptosis in A549, HepG2 and HL-60 cells

From: Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancer cells

Cell line

Group

Apoptosis distribution (%) in cells

Viable cell

Early apoptosis

Late apoptosis

Necrosis

A549

control

91.97 ± 0.34

1.59 ± 0.41

6.08 ± 0.36

0.35 ± 0.11

4.0 µM

76.13 ± 5.99*

6.75 ± 1.04**

16.80 ± 5.08*

0.33 ± 0.02

6.0 µM

61.03 ± 0.99**

9.03 ± 1.27**

29.47 ± 1.08**

0.44 ± 0.12

8.0 µM

47.03 ± 1.43**

9.15 ± 0.92**

35.33 ± 1.72**

8.50 ± 0.92

HepG2

control

89.53 ± 1.37

1.16 ± 0.08

8.54 ± 0.83

0.79 ± 0.52

1.25 µM

88.10 ± 1.21

1.68 ± 0.15**

9.29 ± 1.56

0.93 ± 0.29

2.5 µM

80.83 ± 2.03**

2.70 ± 0.26**

15.40 ± 2.32**

1.07 ± 0.35

5.0 µM

26.33 ± 0.90**

23.23 ± 0.29**

48.43 ± 0.90**

2.02 ± 0.21

HL-60

control

93.37 ± 0.33

1.10 ± 0.06

5.31 ± 0.22

0.23 ± 0.04

2.0 µM

82.77 ± 0.99**

1.72 ± 0.21**

14.97 ± 0.70**

0.58 ± 0.07

4.0 µM

56.33 ± 1.11**

2.38 ± 0.36**

39.40 ± 1.13**

1.93 ± 0.37

6.0 µM

43.00 ± 1.02**

2.24 ± 0.59*

53.53 ± 1.13**

1.25 ± 0.11

  1. Results are expressed as mean ± SD values from three independent experiments.
  2. P-value of less than 0.05 (* P < 0.05, ** P < 0.01, compared with the control group) are considered statistically significant.