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Table 3 Effects of incubation with karanjin for 72 h on cell apoptosis in A549, HepG2 and HL-60 cells

From: Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancer cells

Cell line Group Apoptosis distribution (%) in cells
Viable cell Early apoptosis Late apoptosis Necrosis
A549 control 91.97 ± 0.34 1.59 ± 0.41 6.08 ± 0.36 0.35 ± 0.11
4.0 µM 76.13 ± 5.99* 6.75 ± 1.04** 16.80 ± 5.08* 0.33 ± 0.02
6.0 µM 61.03 ± 0.99** 9.03 ± 1.27** 29.47 ± 1.08** 0.44 ± 0.12
8.0 µM 47.03 ± 1.43** 9.15 ± 0.92** 35.33 ± 1.72** 8.50 ± 0.92
HepG2 control 89.53 ± 1.37 1.16 ± 0.08 8.54 ± 0.83 0.79 ± 0.52
1.25 µM 88.10 ± 1.21 1.68 ± 0.15** 9.29 ± 1.56 0.93 ± 0.29
2.5 µM 80.83 ± 2.03** 2.70 ± 0.26** 15.40 ± 2.32** 1.07 ± 0.35
5.0 µM 26.33 ± 0.90** 23.23 ± 0.29** 48.43 ± 0.90** 2.02 ± 0.21
HL-60 control 93.37 ± 0.33 1.10 ± 0.06 5.31 ± 0.22 0.23 ± 0.04
2.0 µM 82.77 ± 0.99** 1.72 ± 0.21** 14.97 ± 0.70** 0.58 ± 0.07
4.0 µM 56.33 ± 1.11** 2.38 ± 0.36** 39.40 ± 1.13** 1.93 ± 0.37
6.0 µM 43.00 ± 1.02** 2.24 ± 0.59* 53.53 ± 1.13** 1.25 ± 0.11
  1. Results are expressed as mean ± SD values from three independent experiments.
  2. P-value of less than 0.05 (* P < 0.05, ** P < 0.01, compared with the control group) are considered statistically significant.
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