Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases

Table 2 The distribution of Homocysteinemia and, ET-1 concentration patients and healthy subjects and according to risk factors among patients

Populations and risk factors	Hcy (μmol/L)		P	ET-1 (nmol/L)	P
Population	Patients (n = 157)	24.40 ± 12.5	<0.00001	15.2 ± 5.3	<0.00001
Population	Controls (n = 142)	7.4 ± 2.5	<0.00001	7.1 ± 2.7	<0.00001
Gender	Men (n = 121)	24.8 ± 18.2	NS	17.4 ± 4.6	<0.00001
Gender	Women (n = 36)	23.1 ± 6.3	NS	7.8 ± 2.3	<0.00001
Hypertension	Yes (n = 138)	24 ± 8.3	NS	16.4 ± 3.3	<0.00001
Hypertension	No (n = 19)	27.3 ± 16.7	NS	6.6 ± 1.9	<0.00001
Diabetes	Yes (n = 101)	29.4 ± 7.6	<0.00001	15 ± 5.1	NS
Diabetes	No (n = 56)	15.4 ± 6.6	<0.00001	15.6 ± 3.8	NS
Tobacco	Yes (n = 98)	32.4 ± 11.6	<0.00001	11.6 ± 3	<0.00001
Tobacco	No (n = 59)	11.1 ± 2	<0.00001	21.2 ± 6.1	<0.00001
Obesity	Yes (n = 82)	28.2 ± 13	NS	12.2 ± 5.3	<0.001
Obesity	No (n = 75)	20.2 ± 5.3	NS	18.2 ± 4	<0.001
Dyslipidemia	Yes (n = 63)	26.2 ± 8.2	NS	11.8 ± 1.6	<0.00001
Dyslipidemia	No (n = 94)	23.2 ± 7.4	NS	17 .5 ± 4.6	<0.00001
Alcohol	Yes (n = 52)	24.9 ± 10.6	NS	16 ± 4.1	NS
Alcohol	No (n = 105)	24.2 ± 7.3	NS	14.8 ± 3.8	NS
Sedentarity	Yes (n = 67)	25.7 ± 11.1	NS	15.7 ± 3.7	NS
Sedentarity	No (n = 90)	23.5 ± 7.5	NS	14.9 ± 2.4	NS

σ standard deviation, NS not significant, x mean, Hcy homocysteine, ET-1 endothelin-1

ISSN: 0717-6287