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Table 3 AChE & BChE inhibitiory potentials of plant extracts using galanthamine as standard

From: Anticholinesterse and antioxidant investigations of crude extracts, subsequent fractions, saponins and flavonoids of atriplex laciniata L.: potential effectiveness in Alzheimer’s and other neurological disorders

Samples Concentrations ( μ g/mL) Percent Inhibition (AChE) AChE IC 50 ( μ g/mL) Percent inhibition (BChE) BChE IC 50 ( μ g/mL)
Al.MeF 1000 78.65 ± 0.70*** 280 82.68 ± 0.60*** 220
500 67.25 ± 0.55***   69.42 ± 0.60***
250 47.21 ± 0.62***   52.51 ± 0.66***
125 31.55 ± 0.56***   41.27 ± 0.62***
Al.HxF 1000 72.51 ± 0.62***   64.36 ± 0.61*** 400
500 63.44 ± 0.44*** 310 53.40 ± 0.52***
250 42.46 ± 0.47***   39.46 ± 0.60***
125 23.68 ± 0.64***   22.52 ± 0.49***
Al.CfF 1000 67.42 ± 0.46 ***   83.49 ± 0.46*** 160
500 53.53 ± 0.41*** 390 72.48 ± 0.50***
250 40.62 ± 0.69***   59.59 ± 0.66***
125 18.46 ± 0.67***   45.57 ± 0.63***
Al.EaF 1000 77.45 ± 0.55 ***   74.41 ± 0.60*** 260
500 57.63 ± 0.64*** 270 61.53 ± 0.71***
250 48.45 ± 0.66 ***   49.45 ± 0.77***
125 36.36 ± 0.50***   31.75 ± 0.58***
Al.WtF 1000 72.44 ± 0.58***   78.62 ± 0.36*** 210
500 60.51 ± 0.59*** 263 69.22 ± 0.47***
250 48.62 ± 0.70***   52.52 ± 0.71***
125 31.47 ± 0.55***   43.52 ± 0.70***
Al.SPF 1000 84.36 ± 0.64 ***   80.37 ± 0.54*** 120
500 77.34 ± 0.65*** 90 73.44 ± 0.50***
250 65.58 ± 0.67***   62.51 ± 0.72***
125 53.60 ± 0.50***   49.28 ± 0.61***
Al.FLVF 1000 88.31 ± 0.57ns   85.46 ± 0.62*** 100
500 79.46 ± 0.63 * 70 76.58 ± 0.69***
250 67.53 ± 0.49 ***   65.68 ± 0.42***
125 59.38 ± 0.50ns   52.46 ± 0.72***
Galanthamine 1000 91.37 ± 0.65   94.50 ± 0.71 47
500 83.33 ± 0.55 52 85.47 ± 0.59
250 73.31 ± 0.60   71.72 ± 0.51
125 61.32 ± 0.54   65.37 ± 0.69
  1. Result expressed as % inhibition (mean ± SEM of n = 3) and IC50 values. Values significantly different as compared to positive control, *:P < 0.05, ***:P < 0.001, ns: P >0.05.