Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice

Biological Research

Table 1 Histopathological changes in hepatic tissue of mice infected with S. mansoni

Group		Microscopic observation
	Histological activity index^a	Necrosis or apoptosis	Hemorrhage	Disorganized sinusoids	Infiltration of lymphocytes	Hyperplasia of Kupffer cells	Hepatocytic swelling
Control	1	0	0	0	0	0	0
PZQ	3	0	0	+	+	0	0
BER	2	+	0	0	+	0	0
Infected	14-16	+++	+++	++	+++	+++	++
Infected + PZQ	9-11	++	+	+	++	++	+
Infected + BER	9-12	+	+	+	++	+	+

^aModified according to Ishak et al. [17]. Score: 1–3, minimal; 4–8, mild; 9–12, moderate; 13–18, severe. 0: absent; +: mild; ++; moderate; and +++: severe.

ISSN: 0717-6287