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Table 1 Histopathological changes in hepatic tissue of mice infected with S. mansoni

From: Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice

Group   Microscopic observation
  Histological activity indexa Necrosis or apoptosis Hemorrhage Disorganized sinusoids Infiltration of lymphocytes Hyperplasia of Kupffer cells Hepatocytic swelling
Control 1 0 0 0 0 0 0
PZQ 3 0 0 + + 0 0
BER 2 + 0 0 + 0 0
Infected 14-16 +++ +++ ++ +++ +++ ++
Infected + PZQ 9-11 ++ + + ++ ++ +
Infected + BER 9-12 + + + ++ + +
  1. aModified according to Ishak et al. [17]. Score: 1–3, minimal; 4–8, mild; 9–12, moderate; 13–18, severe. 0: absent; +: mild; ++; moderate; and +++: severe.
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