Histological changes in hepatic tissue of non-infected and infected mice with S. mansoni on day 55 p.i. (A) Non-infected liver with normal architecture. (B) Non-infected, PQZ treated mouse liver with normal structure. (C) Non-infected, berberine treated mouse liver with normal structure. (D,E) Infected liver from group 4 with prominent inflammation (black arrow heads) especially around granuloma (black arrow), sinusoidal dilatations (white arrow) and hepatocytic vacuolation. (F,G) Infected PQZ treated mouse liver from group 5 showing fewer lesions. (H,I) Infected berberine treated mouse liver from group 6 showing reduced tissue damage. Sections are stained with hematoxylin and eosin. Bar = 50 μm.