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Table 2 Percent AChE and BChE inhibition potentials of I. rugosus at various tested concentrations

From: Investigations of anticholinestrase and antioxidant potentials of methanolic extract, subsequent fractions, crude saponins and flavonoids isolated from Isodon rugosus

Samples Concentrations (μg/ml) Percent AChE (mean ± SEM) AChE Percent BChE
IC50 BChE IC50
(μg/ml) (mean ± SEM) (μg/ml)
Ir.Sp 1000 77.85 ± 0.56*** 75 69.48 ± 0.74*** 210
500 71.64 ± 0.75*** 62.62 ± 0.40***
250 62.58 ± 0.77*** 51.60 ± 0.46***
Ir.Cr 1000 71.75 ± 0.63*** 140 68.68 ± 0.49*** 145
500 63.58 ± 0.70*** 61.72 ± 0.66***
250 56.61 ± 0.53*** 55.46 ± 0.63***
Ir.Hex 1000 64.79 ± 0.62*** 630 62.61 ± 0.77*** 380
500 45.45 ± 0.49*** 54.60 ± 0.80***
250 43.75 ± 0.58*** 43.83 ± 0.56***
Ir.Cf 1000 83.73 ± 0.64*** 50 88.55 ± 0.77ns 70
500 79.47 ± 0.56*** 83.65 ± 0.77ns
250 67.81 ± 0.60*** 67.58 ± 0.74***
Ir.EtAc 1000 71.74 ± 0.61*** 170 76.37 ± 0.68*** 52
500 69.68 ± 0.60*** 72.66 ± 0.78***
250 52.63 ± 0.76*** 63.62 ± 0.74***
Ir.Aq 1000 66.79 ± 0.63*** 340 71.62 ± 0.74*** 305
500 59.67 ± 0.61*** 63.86 ± 0.60***
250 41.69 ± 0.77*** 44.48 ± 0.64***
Ir.Flv 1000 87.44 ± 0.51*** 45 82.53 ± 0.71*** 40
500 73.76 ± 0.58*** 76.52 ± 0.68***
250 71.54 ± 0.50*** 68.51 ± 0.77***
Galanthamine 1000 96.00 ± 0.30 20 88.61 ± 0.43 47
500 91.26 ± 1.27 83.25 ± 1.40
250 82.91 ± 1.30 74.03 ± 0.86
  1. The data is represented as mean ± SEM, (N = 3). Values significantly different as compare to positive control, *P < 0.05, **P < 0.01, ***P < 0.001.
  2. Abbreviations: Ir.Cr Crude methanolic extract, Ir.Hex n-hexane fraction, Ir.Cf Chloroform fraction, Ir.EtAc Ethyl acetate fraction, Ir.Aq Aqueous fraction, Ir.Flv Crude flavonoids, Ir.Sp Crude Saponins.