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Table 3 Combining multiple test as two-test parallel (A) and serial (B) combination

From: Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population

Test A Sensitivity % (95% CI) Specificity % (95% CI) PPV % (95% CI) PNV % (95% CI)
  LC PNL LC PNL LC PNL LC PNL
DR70 95.8 (78.9- 99.9) 27.3 (6.0-61.0) 91.9 (88.1-94.8) 91.9 (88.1-94.3) 50.0 (35.1 -65.1) 11.5 (2.4 -30.2) 99.6 (97.8 -100) 97.0 (94.2 -98.7)
AQC 64.0 (42.5- 82.0) 90.9 (58.7-99.8) 89.4 (85.2-92.7) 89.4 (85.2-92.7) 34.8 (21.2 -50.4) 25.0 (12.6 -41.4) 96.6 (93.6 -98.6) 99.6 (97.8 -100)
Parallel combined test 92.0 (74.4 -100) 91.2 (83.0-99.5) 80.92 (76.2-85.7) 80.92 (76.2-85.7) 29.9 (19.0 -40.7) 49.1 (39.1 -59.1) 99.1 (97.7 -100) 97.9 (95.8 -99.9)
Test B Sensitivity % (95% CI) Specificity % (95% CI) PPV % (95% CI) PNV % (95% CI)
  LC PNL LC PNL LC PNL LC PNL
DR70 95.8 (78.9- 99.9) 27.3 (6.0-61.0) 91.9 (88.1-94.8) 91.9 (88.1-94.3) 50.0 (35.1 -65.1) 11.5 (2.4 -30.2) 99.6 (97.8 -100) 97.0 (94.2 -98.7)
AQC 64.0 (42.5- 82.0) 90.9 (58.7-99.8) 89.4 (85.2-92.7) 89.4 (85.2-92.7) 34.8 (21.2 -50.4) 25.0 (12.6 -41.4) 96.6 (93.6 -98.6) 99.6 (97.8 -100)
Serial combined test 60.0 (38.8 -81.2) 35.1 (21.8 -48.4) 97.2 (95.1 -99.3) 97.2 (95.1-99.3) 65.2 (43.6 -86.9) 71.4 (52.9 -90.0) 96.5 (94.2 -98.8) 88.1 (84.4 -91.9)
  1. LC: Lung Cancer; PNL: Pre Neoplastic Lesion; PPV: Positive Predictive Value; PNV: Negative Predictive Value; CI: Confidence Interval.