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Table 3 Concentration dependent cytotoxic effect of the Ir.Cr extract of I. rugosus and its fractions against Artemia salina

From: Phytochemical and toxicological investigations of crude methanolic extracts, subsequent fractions and crude saponins of Isodon rugosus

Extracts Total treated Dose (μg/ml) % Lethality (mean ± SEM) LC50(μg/ml)
Ir.Cr 30 1000 71.10 ± 1.1*** 220
100 46.67 ± 3.3***
10 37.77 ± 1.1***
Ir.Hex 30 1000 62.23 ± 2.9*** 120
100 48.90 ± 1.1***
10 40.00 ± 1.9***
Ir.Chf 30 1000 76.67 ± 3.3*** 12
100 62.23 ± 2.9 ns
10 48.90 ± 1.1 ns
Ir.EtAc 30 1000 74.43 ± 2.2*** 315
100 57.77 ± 2.2*
10 43.33 ± 1.9*
Ir.Aq 30 1000 65.57 ± 1.1*** 60
100 53.33 ± 1.9***
10 42.23 ± 1.1**
Ir.Sp 30 1000 92.23 ± 1.1 10
100 66.67 ± 1.9
10 52.23 ± 1.1
  1. Standard drug; Etoposide, LC50 = 9.8 μg/ml. Values represents % lethality and are expressed as mean ± SEM; *P <0.05, **P <0.01, ***P <0.001.