Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation

Table 1 Effects of AELS, AEAR and Standard drug on brewer’s yeast induced pyrexia

Group	Treatment	Dose [mg/kg]	Temp [t₀b]°C	Temp [t₀a]°C	Rectal temperature °C in mean ± SEM
					1 hrs.	2 hrs.	3 hrs.	4 hrs.	5 hrs.
I	Control	---	37.26 ± 0.1	38.3 ± 0.1	38.47 ± 0.1	38.35 ± 0.2	38.28 ± 0.1	38.31 ± 0.1	38.27 ± 0.1
II	Std	250	37.21 ± 0.1	38.1 ± 0.3	37.41 ± 0.3*	36.92 ± 0.2***	36.61 ± 0.1***	36.21 ± 0.2***	35.89 ± 0.1***
III	AELS	100	37.26 ± 0.1	38.2 ± 0.2	38.36 ± 0.11*	38.11 ± 0.1*	38.0 ± 0.13*	37.95 ± 0.12*	37.56 ± 0.1*
IV	AELS	200	37.31 ± 0.3	38.4 ± 0.1	38.14 ± 0.10**	37.85 ± 0.13**	37.67 ± 0.13**	37.23 ± 0.11**	36.98 ± 0.15**
V	AELS	400	37.29 ± 0.1	38.4 ± 0.1	37.93 ± 0.09**	37.47 ± 0.08***	36.92 ± 0.10**	36.43 ± 0.11***	36.38 ± 0.09***
VI	AEAR	100	37.34 ± 0.2	38.3 ± 0.3	37.65 ± 0.10	37.63 ± 0.13	37.55 ± 0.12	37.57 ± 0.10	37.5 ± 0.11
VII	AEAR	200	37.42 ± 0.1	38.0 ± 0.1	37.84 ± 0.11*	37.69 ± 0.10*	37.58 ± 0.14*	37.41 ± 0.20*	37.23 ± 0.18*
VIII	AEAR	400	37.27 ± 0.1	37.5 ± 0.1	37.57 ± 0.17**	37.65 ± 0.15**	37.32 ± 0.13**	36.86 ± 0.11**	36.61 ± 0.18**

Results are expressed as mean ± S.E.M. t₀b = initial body temperature prior to injection of Brewer s yeast, t₀a = body temperature 18 h after injection of brewer s yeast, n = 6 each group, *P < 0.05, **P < 0.01, ***P < 0.001, significantly different value while compared to the control groups, (ANOVA followed by Dunnet’s t-test).

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