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Table 5 Main functions of downregulated miRNAs predicted by bioinformatic analysis

From: Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells

miRNA Putative target genes KEGG pathway Genes involved in the term % of involved genes/total genes p-value
(Homo sapiens)
miR-1290 593 Pathways in cancer 17 2.9 4.00E-02
   Focal adhesion 14 2.4 7.90E-03
   Insulin signaling pathway 13 2.2 7.60E-04
   MAPK signaling pathway 12 2 1.90E-01
   ErbB signaling pathway 11 1.9 2.80E-04
miR-1915-3p 351 Wnt signaling pathway 8 2.3 5.60E-03
   Pathways in cancer 7 2 3.30E-01
miR-2861 170 Fc gamma R-mediated phagocytosis 4 2.2 3.60E-02
   MAPK signaling pathway 6 3.4 5.10E-02
   Arachidonic acid metabolism 3 1.7 6.80E-02
miR-3665 195 Neurotrophin signaling pathway 4 2.1 1.10E-01
   Insulin signaling pathway 4 2.1 1.30E-01
   MAPK signaling pathway 4 2.1 4.70E-01
miR-4257 197 - - - -
miR-452-5p 327 Oocyte meiosis 8 2.3 1.30E-03
   Wnt signaling pathway 7 2 2.60E-02
   ECM-receptor interaction 5 1.4 3.80E-02
miR-513a-5p 980 MAPK signaling pathway 25 2.6 1.00E-02
   Pathways in cancer 24 2.4 1.30E-01
   Regulation of actin cytoskeleton 20 2 2.50E-02
miR-572 6 - - - -
miR-629-3p 445 Pathways in cancer 10 2.3 2.10E-01
miR-765 548 Cytokine-cytokine receptor interaction 11 2 2.00E-01
miR-875-5p 181 MAPK signaling pathway 6 3.3 7.30E-02
   Spliceosome 5 2.8 2.10E-02
miR-940 - - - - -