Table 3 Predicted targets of miRNAs downregulated by arctiin in H ₂ O ₂ -treated HHDPCs

hsa-miR-1290

HMGA2, NUAK1, TERF2, SLC1A2, FADS1, DDC

APC, COL8A1

HMGA2, APC, RRN3, ITGAV, CSE1L, NOTCH1, GAS, BMI1, FOXC1, ROBO1, USP28

HMGA2, BMI1, NUAK1, APC, MLL2, RRN3, ITGAV, CSE1L, NOTCH1, GAS, FOXC1, ROBO1, USP28, CDC27, HES1, COL8A1, NPR3, CDKN2B, FIGF, NRAS

hsa-miR-1915-3p

BCL2, SRF, SREBF2, HSD17B10

SRF, DDR1, EDA

BCL2, MAPK311, ARHGEF2, CDK5R1, WNT3A, MMP9, THRA, MEF2D, SET, CD44

DDR1, CDK2, DEAF1, TIRAP, BCL2, MAP3K11, ARHGEF2, CDK5R1, WNT3A, TNFSF11, WDR6, AZGP1, TAL1, DPT

hsa-miR-2861

P2PY2, FADS1

NGFR, EDA

NGFR, PTPRC, ITGA1, MAEL, FGD2, AKT2, PAX8

NGFR, PTPRC, SLAMF1, HOXB4, AKT2, HOXB4,

hsa-miR-3665

AQP2

-

AQP2, FGFR1, BOK, TRIO, NOTCH1, PGAP2, PDPK1, BARD1

BOK, FEZF1, ABCB1, FOXO4, EIF5A2, WNT9A, NDFIP1, FGFR1, NOTCH1, CDK13

hsa-miR-4257

TWIST1, CTSC, HMGA1

COL2A1

TWIST1, CTSC, IGF1R, IL10, GSK3B, RASSF5, COL2A1, AKT1S1, CD44, ASAH2

TWIST1, HMGA1, IL10, INSR, MAPRE2, PA2G4, PRDM1, IGF1R, MMP14, EMX2, TRIM27, MCM7

hsa-miR-452-5p

TIMP3

-

SPRY2, PAX3, SOX7, LRP6, SNAI2, CSNK2A2, FGD4, PKN2, ITGA6, PDCD6IP

SPRY2, PAX3, SOX7, LRP6, SNAI2, RPA1, EPS8, NFIB, MAPRE1, ODZ1, CDCA7L, CD47, E2F3, PURA, RUNX1

hsa-miR-513a-5p

SERP1, NEK6, CDK6, DLD, PRKCD, MAP2K1, MORC3, LRRK2, SLC1A2

WNT7A, SFN, TFAP2B, APC

SPRY2, MLL, GATA3, BCL6, PRKCD, NEK6, MED1, PLK2, WNT7A, SFN, APC, HOXA5, AKAP13, USP47, MAP2K4, ISL1, MITF, STAT1, XIAP, TFAP2B, HDAC2, TRIM2, CREB1, MAP3K7, WNK3, SOS1, FGD4

TFAP2B, WNT7A, APC, HGF, EBXW7, TSC1, KRAS, RXRB, XIAP, SPRY2, GATA3, BCL6, HOXA5, ISL1, MITF, STAT1, NFIB, E2F7, MAGI2, PDKK, HDAC2, MED1, EHF, LIFR, PURA, GATA2, ATF3, VIP, SOX11, RUNX1, RNF139, PCM1, TSHR, EPS8

hsa-miR-572

-

-

-

-

hsa-miR-629-3p

SOD2, VDR, EDN1, CHEK1, SLC34A2

-

THOC1, MYO18A, TP53BP2, SOD2, VDR, EDN1, APC, PPARG, PIM1, ERBB4, PSMD2, PERP, BCL2L15

DLG3, RTKN2, CDK9, STAT3, SOD2, VDR, EDN1, PPARG, PIM1, ERBB4, APC, STAT6, PDGFC, ZEB1, ID4, LIFR, NOLC1, EPHB1, ACSL6, EREG, CDK13, CDC27

hsa-miR-765

VDR, RELA, SOCS3, TIMP3, LOXL2

PDGFA, ERRFI1

DLG5, RARG, MED1, EGLN2, VDR, RELA, SOCS3, ERBB4, RNF41, ATG7, ARHGEF11, PDE5A, CXCL12, GLI3, DIDO1, CASP9, ACIN1

CXCL12, GLI3, DLG5, RARG, VDR, RELA, ERBB4, PDE5A, MED1, PDGFA, CD34, GPC3, PDX1, COL8A1, PES1, TSC2, SF1, FTO, GABBR1,

hsa-miR-875-5p

TGFB3, SMC5

TCF7L2

TGFB3, TCF7L2, EYA1, MDM4, MEF2C, EGFR, WNK3

MDM4, MEF2C, EGFR, FRS2, TGFB3, EYA1, TOB2, TBX18, CEP120, TCF7L2, TIRAP, RNF139, SALL1

hsa-miR-940

-

-

-

-