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Table 3 Predicted targets of miRNAs downregulated by arctiin in H 2 O 2 -treated HHDPCs

From: Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells

miRNA Target genes and functions
Aging Skin development Apoptosis Cell proliferation
hsa-miR-1290 HMGA2, NUAK1, TERF2, SLC1A2, FADS1, DDC APC, COL8A1 HMGA2, APC, RRN3, ITGAV, CSE1L, NOTCH1, GAS, BMI1, FOXC1, ROBO1, USP28 HMGA2, BMI1, NUAK1, APC, MLL2, RRN3, ITGAV, CSE1L, NOTCH1, GAS, FOXC1, ROBO1, USP28, CDC27, HES1, COL8A1, NPR3, CDKN2B, FIGF, NRAS
hsa-miR-1915-3p BCL2, SRF, SREBF2, HSD17B10 SRF, DDR1, EDA BCL2, MAPK311, ARHGEF2, CDK5R1, WNT3A, MMP9, THRA, MEF2D, SET, CD44 DDR1, CDK2, DEAF1, TIRAP, BCL2, MAP3K11, ARHGEF2, CDK5R1, WNT3A, TNFSF11, WDR6, AZGP1, TAL1, DPT
hsa-miR-2861 P2PY2, FADS1 NGFR, EDA NGFR, PTPRC, ITGA1, MAEL, FGD2, AKT2, PAX8 NGFR, PTPRC, SLAMF1, HOXB4, AKT2, HOXB4,
hsa-miR-3665 AQP2 - AQP2, FGFR1, BOK, TRIO, NOTCH1, PGAP2, PDPK1, BARD1 BOK, FEZF1, ABCB1, FOXO4, EIF5A2, WNT9A, NDFIP1, FGFR1, NOTCH1, CDK13
hsa-miR-4257 TWIST1, CTSC, HMGA1 COL2A1 TWIST1, CTSC, IGF1R, IL10, GSK3B, RASSF5, COL2A1, AKT1S1, CD44, ASAH2 TWIST1, HMGA1, IL10, INSR, MAPRE2, PA2G4, PRDM1, IGF1R, MMP14, EMX2, TRIM27, MCM7
hsa-miR-452-5p TIMP3 - SPRY2, PAX3, SOX7, LRP6, SNAI2, CSNK2A2, FGD4, PKN2, ITGA6, PDCD6IP SPRY2, PAX3, SOX7, LRP6, SNAI2, RPA1, EPS8, NFIB, MAPRE1, ODZ1, CDCA7L, CD47, E2F3, PURA, RUNX1
hsa-miR-513a-5p SERP1, NEK6, CDK6, DLD, PRKCD, MAP2K1, MORC3, LRRK2, SLC1A2 WNT7A, SFN, TFAP2B, APC SPRY2, MLL, GATA3, BCL6, PRKCD, NEK6, MED1, PLK2, WNT7A, SFN, APC, HOXA5, AKAP13, USP47, MAP2K4, ISL1, MITF, STAT1, XIAP, TFAP2B, HDAC2, TRIM2, CREB1, MAP3K7, WNK3, SOS1, FGD4 TFAP2B, WNT7A, APC, HGF, EBXW7, TSC1, KRAS, RXRB, XIAP, SPRY2, GATA3, BCL6, HOXA5, ISL1, MITF, STAT1, NFIB, E2F7, MAGI2, PDKK, HDAC2, MED1, EHF, LIFR, PURA, GATA2, ATF3, VIP, SOX11, RUNX1, RNF139, PCM1, TSHR, EPS8
hsa-miR-572 - - - -
hsa-miR-629-3p SOD2, VDR, EDN1, CHEK1, SLC34A2 - THOC1, MYO18A, TP53BP2, SOD2, VDR, EDN1, APC, PPARG, PIM1, ERBB4, PSMD2, PERP, BCL2L15 DLG3, RTKN2, CDK9, STAT3, SOD2, VDR, EDN1, PPARG, PIM1, ERBB4, APC, STAT6, PDGFC, ZEB1, ID4, LIFR, NOLC1, EPHB1, ACSL6, EREG, CDK13, CDC27
hsa-miR-765 VDR, RELA, SOCS3, TIMP3, LOXL2 PDGFA, ERRFI1 DLG5, RARG, MED1, EGLN2, VDR, RELA, SOCS3, ERBB4, RNF41, ATG7, ARHGEF11, PDE5A, CXCL12, GLI3, DIDO1, CASP9, ACIN1 CXCL12, GLI3, DLG5, RARG, VDR, RELA, ERBB4, PDE5A, MED1, PDGFA, CD34, GPC3, PDX1, COL8A1, PES1, TSC2, SF1, FTO, GABBR1,
hsa-miR-875-5p TGFB3, SMC5 TCF7L2 TGFB3, TCF7L2, EYA1, MDM4, MEF2C, EGFR, WNK3 MDM4, MEF2C, EGFR, FRS2, TGFB3, EYA1, TOB2, TBX18, CEP120, TCF7L2, TIRAP, RNF139, SALL1
hsa-miR-940 - - - -