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Table 2 Predicted targets of miRNAs upregulated by arctiin in H 2 O 2 -treated HHDPCs

From: Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells

miRNA Target genes and functions
Aging Skin development Apoptosis Cell proliferation
hsa-miR-1181 - - - -
hsa-miR-125a-5p EPO, EDN1, BCL2, BAK1, CASP2, PTH1R COL4A3 ITCH, COL4A3, HIPK2, RAF1, EPO, EDN1, BCL2, MAP2K7, MAP3K1, ARHGEF3, TRAF6, CASP2, BAK1, IRF1, APPL1, ETS1, BMF, MCL1, BCL2L2, BAG4, HK2, FOXQ1, CREB1, E2F2, TP73, USP7, MAPK7, FGFR2, BRCA1, MAP3K11, REST, DICER1, ARHGEF2, MAP3K10, SORT1, BNIP2, DDX5, CSNK2A1, MKNK2 BRCA1, MAP3K11, ETS1, LIF, SOX11, CD34, NCOR2, BAP1, IRF1, APPL1, REST, DICER1, EPO, EDN1, BCL2, BAK1, ARHGEF2, FGFR2, ITCH, ABCB1, COL4A3, KIF15, HIPK2, RAF1, EIF5A2, CARM1
hsa-miR-21-3p CDK6 - MAP2K4, MAP3K1, BCL2L11, ROBO2, RNF41, BAG4, CUL3, FOXO3, SMAD3, AMIGO2, KDM28, DAB2IP, TRIM32, SOX4, CCAR1, SLC11A2, DSG1 CDK6, KDM28, CUL3, SOX4, SMAD3, NR6A1, FTO, CD274, DAB2IP, TRIM32, FOXO3, PBRM1
hsa-miR-29b-1-5p NR3C1, SIRT1 - NR3C1, SIRT1, REST, PTK2, SOS2, NUAK2, PSMD7 NR3C1, SIRT1, REST, PTK2, FGF18, INSR, PBRM1
hsa-miR-3663-3p FAS, CASP2, CDKN1A, PTH1R ADAMTS2, BCL11B, COL3A1, COL1A1 CDKN1A, BCL11B, PPP2R1B, TGFB2, DDX5, COMP, PIGT, FAS, USP28, TIAL1, CASP2, PSMA2, MEF2D FAS, USP28, TIAL1, TGFB2, CDKN1A, BCL11B, VSIG
hsa-miR-371a-5p - LEF1, ATP7A, COL8A1 LEF1, SOX2, CITED2, STK4, RB1CC1, BARD1, RPS6KA1, GSK3B, PSMF1, MAP3K1, NR4A2, DYRK2, ITSN1, LEF1, SOX2, CITED2, STK4, COL8A1, RNF10, MAPRE1, BTG3, CCR2, FRS2, PRMT5
hsa-miR-4327 RPS6KB1 STS RPS6KB1, ADAMTS20, FGF10, IGF1R, FGD4, RPS6KA3 RPS6KB1, IGF1R, FGF10, STS, PROX1, NF2, IFNK
hsa-miR-584-5p SOD2, MORC3 PTCH2 SOD2, SIX1, LRP6, FGF10, TRIM24, HDAC1, CUL2, SRPK2, NBN, ETS1, DSG3, MTDH, PDE3A, SLAMF7 SOD2, SIX1, LRP6, FGF10, TRIM24, HDAC1, CUL2, SRPK2, NBN, ETS1, PRRX1, FER, USP8, WWTR1
hsa-miR-602 EDN1, VDR, SOD2, HTT, SLC34A2, CHEK1 APC EDN1, VDR, SOD2, HTT, APC, NOG, ERBB4, PIM1, PPARG, ALDH1A2, CLI2, SEMA3A, H1F0, DYRK2, BCL2L15, JMY, PSMD2, TP53BP2, MYO18A, SHF NOG, ERBB4, PIM1, PPARG, CLI2, CDK13, LIFR, STAT3, EDN1, VDR, SOD2, CDC27, EMX2, CDK9, RTKN2, ID4, APC, ALDH1A2, PPP1R8, ACSL6, ZEB1
hsa-miR-642b-3p HMGA2, PTEN, CDKN1A, SERPINE1, MET BCL11B SERPINE1, BCL11B, PDCD10, HMGA2, PTEN, RB1, CYLD, EIF2AK2, BCLAF1, MAPK8, CDKN1A, WT1, CDK5R1, MTCH1, EPHA7, NR4A3, CSNK2A1 SERPINE1, BCL11B, PDCD10, HMGA2, PTEN, WT1, AMBN, CDKN1A, CDK5R1, RB1, PAX6, NR2F2, PHOX2B
hsa-miR-651 - - BTC, MED1, ATG3, CHMP3 CTC, MED1
hsa-miR-762 RELA, PML - RELA, PML, MAPK1, SOX7, ITCH, HIPK2, BCL6, PPARD, CX3CL1, AGAP2, MYO18A, PAK4, ABR, CLIP3, ADD1, PAX7, ITGB2, PDE1B, MAP3K9 EFNB1, LIFR, MMP14, BAP1, RELA, PML, MAPK1, SOX7, PAK4, ITCH, HIPK2, BCL6, CX3CL1, AGAP2, PPARD, NRARP, PTCH1, WARS, FTO
hsa-miR-874 DDC - ESR1, ALDH1A2, HIPK2, PAK7, GZMB, IKBKB, SORT1 ESR1, ALDH1A2, HIPK2, PAK7, RXRB, COMT
hsa-miR-890 CDK6, SERP1, F3, PDCD4, ATP5G3, TIMP3 TCF7L2, ITGA2, ERRFI1 SORT1, UBE2B, MAX, PEG3, F3, PDCD4, TCF7L2, SNAI2, AIPL1, AKAP13, ALB, TRIO, REST, PROK2, KRIT, NF1, APBB1, PSME2 F3, CDK6, TCF7L2, SNAI2, REST, PROK2, KRIT, NF1, EGF, SOX17, MARCKSL1, WARS, EPS8,
hsa-miR-939 TIMP1, ATM, CDKN1A, NEK6, SCL34A2, PRELP, SLC1A2 NGFR, COL1A1 TNF, BCL6, BTC, NRG1, IHH, THRA, IP6K2, PAX7, CASP10, CDKN1A, CAMK1D, TRAIP, WNK3, CLIP3, MT3, INHBB, TIMP1, ATM, NEK6, NGFR, NACC1, USP7, CSNK2A2, BCL2L2 BCL6, BTC, NRG1, IHH, GRN, TRAIP, CDKN1A, TNF, E2F8, RXRB, RARA, DRD2, CSF1, TIMP1, ATM, NGFR, MT3, NOS2, AGGF1, ELN