Table 2 Predicted targets of miRNAs upregulated by arctiin in H ₂ O ₂ -treated HHDPCs

hsa-miR-1181

-

-

-

-

hsa-miR-125a-5p

EPO, EDN1, BCL2, BAK1, CASP2, PTH1R

COL4A3

ITCH, COL4A3, HIPK2, RAF1, EPO, EDN1, BCL2, MAP2K7, MAP3K1, ARHGEF3, TRAF6, CASP2, BAK1, IRF1, APPL1, ETS1, BMF, MCL1, BCL2L2, BAG4, HK2, FOXQ1, CREB1, E2F2, TP73, USP7, MAPK7, FGFR2, BRCA1, MAP3K11, REST, DICER1, ARHGEF2, MAP3K10, SORT1, BNIP2, DDX5, CSNK2A1, MKNK2

BRCA1, MAP3K11, ETS1, LIF, SOX11, CD34, NCOR2, BAP1, IRF1, APPL1, REST, DICER1, EPO, EDN1, BCL2, BAK1, ARHGEF2, FGFR2, ITCH, ABCB1, COL4A3, KIF15, HIPK2, RAF1, EIF5A2, CARM1

hsa-miR-21-3p

CDK6

-

MAP2K4, MAP3K1, BCL2L11, ROBO2, RNF41, BAG4, CUL3, FOXO3, SMAD3, AMIGO2, KDM28, DAB2IP, TRIM32, SOX4, CCAR1, SLC11A2, DSG1

CDK6, KDM28, CUL3, SOX4, SMAD3, NR6A1, FTO, CD274, DAB2IP, TRIM32, FOXO3, PBRM1

hsa-miR-29b-1-5p

NR3C1, SIRT1

-

NR3C1, SIRT1, REST, PTK2, SOS2, NUAK2, PSMD7

NR3C1, SIRT1, REST, PTK2, FGF18, INSR, PBRM1

hsa-miR-3663-3p

FAS, CASP2, CDKN1A, PTH1R

ADAMTS2, BCL11B, COL3A1, COL1A1

CDKN1A, BCL11B, PPP2R1B, TGFB2, DDX5, COMP, PIGT, FAS, USP28, TIAL1, CASP2, PSMA2, MEF2D

FAS, USP28, TIAL1, TGFB2, CDKN1A, BCL11B, VSIG

hsa-miR-371a-5p

-

LEF1, ATP7A, COL8A1

LEF1, SOX2, CITED2, STK4, RB1CC1, BARD1, RPS6KA1, GSK3B, PSMF1, MAP3K1, NR4A2, DYRK2, ITSN1,

LEF1, SOX2, CITED2, STK4, COL8A1, RNF10, MAPRE1, BTG3, CCR2, FRS2, PRMT5

hsa-miR-4327

RPS6KB1

STS

RPS6KB1, ADAMTS20, FGF10, IGF1R, FGD4, RPS6KA3

RPS6KB1, IGF1R, FGF10, STS, PROX1, NF2, IFNK

hsa-miR-584-5p

SOD2, MORC3

PTCH2

SOD2, SIX1, LRP6, FGF10, TRIM24, HDAC1, CUL2, SRPK2, NBN, ETS1, DSG3, MTDH, PDE3A, SLAMF7

SOD2, SIX1, LRP6, FGF10, TRIM24, HDAC1, CUL2, SRPK2, NBN, ETS1, PRRX1, FER, USP8, WWTR1

hsa-miR-602

EDN1, VDR, SOD2, HTT, SLC34A2, CHEK1

APC

EDN1, VDR, SOD2, HTT, APC, NOG, ERBB4, PIM1, PPARG, ALDH1A2, CLI2, SEMA3A, H1F0, DYRK2, BCL2L15, JMY, PSMD2, TP53BP2, MYO18A, SHF

NOG, ERBB4, PIM1, PPARG, CLI2, CDK13, LIFR, STAT3, EDN1, VDR, SOD2, CDC27, EMX2, CDK9, RTKN2, ID4, APC, ALDH1A2, PPP1R8, ACSL6, ZEB1

hsa-miR-642b-3p

HMGA2, PTEN, CDKN1A, SERPINE1, MET

BCL11B

SERPINE1, BCL11B, PDCD10, HMGA2, PTEN, RB1, CYLD, EIF2AK2, BCLAF1, MAPK8, CDKN1A, WT1, CDK5R1, MTCH1, EPHA7, NR4A3, CSNK2A1

SERPINE1, BCL11B, PDCD10, HMGA2, PTEN, WT1, AMBN, CDKN1A, CDK5R1, RB1, PAX6, NR2F2, PHOX2B

hsa-miR-651

-

-

BTC, MED1, ATG3, CHMP3

CTC, MED1

hsa-miR-762

RELA, PML

-

RELA, PML, MAPK1, SOX7, ITCH, HIPK2, BCL6, PPARD, CX3CL1, AGAP2, MYO18A, PAK4, ABR, CLIP3, ADD1, PAX7, ITGB2, PDE1B, MAP3K9

EFNB1, LIFR, MMP14, BAP1, RELA, PML, MAPK1, SOX7, PAK4, ITCH, HIPK2, BCL6, CX3CL1, AGAP2, PPARD, NRARP, PTCH1, WARS, FTO

hsa-miR-874

DDC

-

ESR1, ALDH1A2, HIPK2, PAK7, GZMB, IKBKB, SORT1

ESR1, ALDH1A2, HIPK2, PAK7, RXRB, COMT

hsa-miR-890

CDK6, SERP1, F3, PDCD4, ATP5G3, TIMP3

TCF7L2, ITGA2, ERRFI1

SORT1, UBE2B, MAX, PEG3, F3, PDCD4, TCF7L2, SNAI2, AIPL1, AKAP13, ALB, TRIO, REST, PROK2, KRIT, NF1, APBB1, PSME2

F3, CDK6, TCF7L2, SNAI2, REST, PROK2, KRIT, NF1, EGF, SOX17, MARCKSL1, WARS, EPS8,

hsa-miR-939

TIMP1, ATM, CDKN1A, NEK6, SCL34A2, PRELP, SLC1A2

NGFR, COL1A1

TNF, BCL6, BTC, NRG1, IHH, THRA, IP6K2, PAX7, CASP10, CDKN1A, CAMK1D, TRAIP, WNK3, CLIP3, MT3, INHBB, TIMP1, ATM, NEK6, NGFR, NACC1, USP7, CSNK2A2, BCL2L2

BCL6, BTC, NRG1, IHH, GRN, TRAIP, CDKN1A, TNF, E2F8, RXRB, RARA, DRD2, CSF1, TIMP1, ATM, NGFR, MT3, NOS2, AGGF1, ELN