In vivo antipyretic, antiemetic, in vitro membrane stabilization, antimicrobial, and cytotoxic activities of different extracts from Spilanthes paniculata leaves

Table 1 Effect of the crude, n-hexane, and ethyl acetate extracts of S. paniculata on yeast-induced pyrexia in mice

Treatment	Dose mg/kg	Mean ± SEM rectal temperature (°C)
		0 h	1 h	2 h	3 h	4 h	5 h
Control	-	37.4 ± 0.5	36.9 ± 0.5	37.03 ± 0.12	37.07 ± 0.12	37.03 ± 0.13	36.9 ± 0.7
Standard (Paracetamol)	150	37.2 ± 0.1	36.5 ± 0.6**	36.8 ± 0.26	36.77 ± 0.18**	36.9 ± 0.31	36.7 ± 0.70**
Crude extract	400	37.03 ± 0.2	36.8 ± 0.6	37.2 ± 0.07	36.93 ± 0.15	37 ± 0.26	36.8 ± 0.61
n-hexane extract	400	36.9 ± 0.4	36.7 ± 0.6**	36.7 ± 0.37	36.77 ± 0.12**	36.82 ± 0.41	36.7 ± 0.63**
Ethyl acetate extract	400	37 ± 0.3	36.8 ± 0.6	36.8 ± 0.26	37.03 ± 0.24	37.1 ± 0.23	36.8 ± 0.63

Here, **Significant difference at P < 0.05 vs. control (n = 5); SEM = standard error mean.

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