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Table 4 Mean FEV 1 and FVC indexes across SNP genotypes

From: Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population

SNP genotypes Lung function indexes
  FEV1(mean +/-s.d.) FVC (mean+/-s.d.)
n 98 98
IL13-c.144 G/A GG 98.42 + -13.95 96.33 + -11.88
  GA 93.44 + -16.58 92.15 + -14.79
  AA 92.50 + -7.78 89.50 + -12.02
IL4-590 C/T CC 99.92 + -14.28 96.87 + -11.28
  CT 91.69 + -14.41 92.13 + -14.79
  TT 90.00 + -12.00 87.67 + 16.04
F p-value 0.024  
Dominant model CT/TT vs CC 0.006  
IL4-RP2 253/183 253253 99.75 + -14.15 97.07 + -11.34
  183253 90.59 + -14.52 90.74 + -14.89
  183183 90.00 + -12.00 87.67 + -16.04
F p-value 0.015  
Dominant model 183253/183183 vs 253253 0.004  
ADRB2-c.16 A/G AA 95.16 + -19.79 91.74 + -16.20
  AG 95.91 + -12.83 94.91 + -11.95
  GG 99.47 + -13.94 97.19 + -11.62
ADAM33-V4 C/G GG 99.00 + -0 c 98.00 + -0c
  CG 94.65 + -15.66 94.26 + -10.19
  CC 97.61 + -14.53 95.24 + -13.61
ADAM33-S1c.710 G/A GG 97.13 + -14.81 95.22 + -13.05
  GA 94.29 + -13.96 92.71 + -8.92
  AA - -
GSDML-236 C/T CC 99.13 + -13.20 94.25 + -12.07
  CT 96.30 + -17.48 94.13 + -14.34
  TT 96.75 + -11.34 96.56 + -11.04
STAT6-21 C/T CC 97.34 + -15.74 95.00 + -14.28
  CT 96.49 + -13.52 94.24 + -11.73
  TT 96.92 + -15.73 97.69 + -11.01
  1. c n = 1.
  2. A Shapiro-Wilkoxon test showed that FEV1 is normally distributed (p > 0.05) while FVC is not (p = 0.008). Thus, ANOVA was used for FEV1 analysis while a Kruskal-Wallis test was used for FVC.
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