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Table 3 SNP genotypic frequencies for the Madeira reference set and asthmatics study population

From: Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population

SNP genotypes Study sample set
  Madeira reference set Overall asthma Intermittent asthma Persistent asthma Mild Moderate-severe
  105a 98 24 74 44 30
IL4-590 C/T       
CC 0.800 0.643 0.708 0.622 0.705 0.500
CT 0.191 0.327 0.250 0.351 0.295 0.433
TT 0.009 0.031 0.042 0.027 0 0.067
p-value   0.009   0.006   0.002
OR (95%CI)   2.222 (1.191-4.146)   2.433 (1.264-4.717)   4.000 (1.701-9.434)
IL4-RP2 253/183       
253253 0.818 0.694 0.792 0.662 0.750 0.533
183253 0.155 0.276 0.167 0.311 0.250 0.400
183183 0.027 0.031 0.042 0.027 0 0.067
p-value   0.027   0.013   0.002
OR (95%CI)   1.984 (1.040 -3.788)   2.296 (1.159 -4.547)   3.938 (1.657- 9.357)
IL13-c.144 G/A       
GG 0.676 0.704 0.625 0.730 0.773 0.667
GA 0.305 0.267 0.333 0.257 0.205 0.333
AA 0.019 0.020 0.042 0.014 0.023 0
ADRB2-c.16 A/G       
AA 0.181 0.194 0.250 0.176 0.250 0.067
AG 0.457 0.480 0.458 0.486 0.364 0.667
GG 0.362 0.327 0.292 0.338 0.386 0.267
p-value       0.010*
OR (95%CI)       3.500 (1.318-9.293)
ADAM33-V4 C/G       
GG 0.029 0.010 0 0.014 0.023 0
CG 0.209 0.235 0.292 0.216 0.182 0.267
CC 0.762 0.755 0.708 0.770 0.795 0.733
ADAM33-S1c.710      
G/A GG 0.905 0.929 0.917 0.932 0.932 0.933
GA 0.095 0.071 0.083 0.068 0.068 0.067
AA 0 0 0 0 0 0
GSDML-236 C/T       
CC 0.171 0.163 0.167 0.162 0.136 0.200
CT 0.467 0.469 0.500 0.459 0.364 0.600
TT 0.362 0.367 0.333 0.378 0.500 0.200
p-value       0.008**
OR (95%CI)       0.250 (0.086-0.730)
STAT6-21 C/T b       
CC 0.428 0.449 0.417 0.459 0.523 0.367
CT 0.486 0.418 0.458 0.405 0.295 0.567
TT 0.086 0.133 0.125 0.135 0.182 0.067
  1. a) Except for IL4-590 and IL4-RP2 (n = 110);
  2. b) Polymorphism not in HWE for mild asthma (p-value = 0.038).
  3. χ2 (or Fisher’s exact test when appropriate) significant p-values and OR (95%CI), using the Madeira reference set as a control, are shown in bold (dominant model).
  4. * Heterozygote model, significant p-values and OR (95%CI) for comparison between mild persistent and moderate-severe persistent; Dominant model, Fisher’s exact test p-value = 0.038, OR (95%CI) 4.667 (0.953-22.851); ** Recessive model, significant p-values and OR (95%CI) for comparison between mild persistent and moderate-severe persistent; Heterozygote model: Fisher’s exact test p-value = 0.039, OR 2.625 (1.011-6.817).
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