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Table 3 SNP genotypic frequencies for the Madeira reference set and asthmatics study population

From: Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population

SNP genotypes

Study sample set

 

Madeira reference set

Overall asthma

Intermittent asthma

Persistent asthma

Mild

Moderate-severe

 

105a

98

24

74

44

30

IL4-590 C/T

      

CC

0.800

0.643

0.708

0.622

0.705

0.500

CT

0.191

0.327

0.250

0.351

0.295

0.433

TT

0.009

0.031

0.042

0.027

0

0.067

p-value

 

0.009

 

0.006

 

0.002

OR (95%CI)

 

2.222 (1.191-4.146)

 

2.433 (1.264-4.717)

 

4.000 (1.701-9.434)

IL4-RP2 253/183

      

253253

0.818

0.694

0.792

0.662

0.750

0.533

183253

0.155

0.276

0.167

0.311

0.250

0.400

183183

0.027

0.031

0.042

0.027

0

0.067

p-value

 

0.027

 

0.013

 

0.002

OR (95%CI)

 

1.984 (1.040 -3.788)

 

2.296 (1.159 -4.547)

 

3.938 (1.657- 9.357)

IL13-c.144 G/A

      

GG

0.676

0.704

0.625

0.730

0.773

0.667

GA

0.305

0.267

0.333

0.257

0.205

0.333

AA

0.019

0.020

0.042

0.014

0.023

0

ADRB2-c.16 A/G

      

AA

0.181

0.194

0.250

0.176

0.250

0.067

AG

0.457

0.480

0.458

0.486

0.364

0.667

GG

0.362

0.327

0.292

0.338

0.386

0.267

p-value

     

0.010*

OR (95%CI)

     

3.500 (1.318-9.293)

ADAM33-V4 C/G

      

GG

0.029

0.010

0

0.014

0.023

0

CG

0.209

0.235

0.292

0.216

0.182

0.267

CC

0.762

0.755

0.708

0.770

0.795

0.733

ADAM33-S1c.710 

      

G/A GG

0.905

0.929

0.917

0.932

0.932

0.933

GA

0.095

0.071

0.083

0.068

0.068

0.067

AA

0

0

0

0

0

0

GSDML-236 C/T

      

CC

0.171

0.163

0.167

0.162

0.136

0.200

CT

0.467

0.469

0.500

0.459

0.364

0.600

TT

0.362

0.367

0.333

0.378

0.500

0.200

p-value

     

0.008**

OR (95%CI)

     

0.250 (0.086-0.730)

STAT6-21 C/T b

      

CC

0.428

0.449

0.417

0.459

0.523

0.367

CT

0.486

0.418

0.458

0.405

0.295

0.567

TT

0.086

0.133

0.125

0.135

0.182

0.067

  1. a) Except for IL4-590 and IL4-RP2 (n = 110);
  2. b) Polymorphism not in HWE for mild asthma (p-value = 0.038).
  3. χ2 (or Fisher’s exact test when appropriate) significant p-values and OR (95%CI), using the Madeira reference set as a control, are shown in bold (dominant model).
  4. * Heterozygote model, significant p-values and OR (95%CI) for comparison between mild persistent and moderate-severe persistent; Dominant model, Fisher’s exact test p-value = 0.038, OR (95%CI) 4.667 (0.953-22.851); ** Recessive model, significant p-values and OR (95%CI) for comparison between mild persistent and moderate-severe persistent; Heterozygote model: Fisher’s exact test p-value = 0.039, OR 2.625 (1.011-6.817).
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Biological Research

ISSN: 0717-6287

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