TY - JOUR AU - Repsold, Lisa AU - Mqoco, Thandi AU - Wolmarans, Elize AU - Nkandeu, Sandra AU - Theron, Joji AU - Piorkowski, Tomek AU - du Toit, Peet AU - van Papendorp, Dirk AU - Joubert, Annie Margaretha PY - 2014 DA - 2014/09/04 TI - Ultrastructural changes of erythrocytes in whole blood after exposure to prospective in silico-designed anticancer agents: a qualitative case study JO - Biological Research SP - 39 VL - 47 IS - 1 AB - Novel, in silico-designed anticancer compounds were synthesized in our laboratory namely, 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) and 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16). These compounds were designed to have improved bioavailability when compared to their source compound, 2-methoxyestradiol. This theoretically would be due to their increased binding affinity to carbonic anhydrase II, present in erythrocytes. Since the novel compounds under investigation are proposed to be transported within erythrocytes bound to carbonic anhydrase II, the morphological effect which they may exert on whole blood and erythrocytes is of great significance. A secondary outcome included revision of previously reported procedures for the handling of the whole blood sample. SN - 0717-6287 UR - https://doi.org/10.1186/0717-6287-47-39 DO - 10.1186/0717-6287-47-39 ID - Repsold2014 ER -