Figure 3

Cx inhibits microvascular density of a murine A/J mammary tumor (TA3-MTXR). Histological sections stained with Arteta were visualized at 400× in an optical microscopy and blood vessels were counted. Left panel shows a representative section of untreated primary tumor (A) or Cx-treated (B). Blood vessels were counted (C) and a statistical significance was found (***: p < 0.0001). Right panel shows a representative section of untreated lung metastasis (D) or Cx-treated (E). Blood vessels were counted (F) and a statistical significance was found (*: p = 0.0031). Blood vessels are represented by black arrows.