1 Splenic cells from mice fed with lutein extracts from silk cocoons or marigolds were cultured with ConA at 37°C in 5% CO2 atmosphere. After 72 hours, supernatants were harvested and analyzed by sandwich ELISA. Values represent means ± SEM. * P < 0.05; ** P < 0.01 compared to the control. SLT10, SLT20; silk lutein extract 10 and 20 mg/kg groups, CLT10, CLT20; marigold lutein extract 10 and 20 mg/kg groups.