ncRNA type | ncRNA name | Target genes and pathways | Transgenic mice | Function | Ref |
---|---|---|---|---|---|
miRNA | miR-455-5p and − 3p | EPAS1; HIF-2α Mmp3 Mmp13 | miR-455-/- | miR-455 KO developed cartilage degeneration mimicking OA and elevated expression of cartilage degeneration-related genes | [183] |
miRNA | miR-455-3p | PAK2; TGF-β signaling | miR-455-3p-/- | miR-455-3p inhibits cartilage degeneration | [184] |
miRNA | miR-21-5p | Spry1; ERK-MAPK signaling | miR-21-5p-/- | Promoting the process of TMJOA | [188] |
miRNA | miR-21-5p | FGF18 | miR-21-5pfl/fl; Col2a1-CreER | The articular cartilage degradation of miR-21-5p conditional knockout mice was significantly alleviated in spontaneous destabilization of the medial meniscus models. | [187] |
miRNA | miR-483-5p | Matn3 Timp2 | pri-miR-483 TG mice | Intra-articular injection of lentivirus LV3-miR-483-5p or TG483 mice exhibited significant acceleration and increased severity of OA | [192] |
miRNA | miR-483-5p | mTORC1-HDAC4‐miR‐483‐5p pathway | TSC1f/f; Col2a1-Cre pri-miR-483 TG mice | N.A | [193] |
miRNA | miR-34a-5p | miR-34a-/- | miR-34a-KO mice exhibited protection against DMM-induced cartilage damage | [205] | |
miRNA | miR-204/211 | Runx2; Akt signaling | miR-204 fl/fl; miR-211 fl/fl; Prx1-Cre or CMV-Cre | Maintaining healthy homeostasis of mesenchymal joint cells to counteract OA pathogenesis | [157] |
miRNA | miR-146a | Camk2d Ppp3r2 | miR-146a-/- | miR-146a KO mice was alleviated in spontaneous and instability-induced OA models | [191] |
miRNA | miR-140 | Adamts-5 | miR-140-/- | Loss of miR-140 contributes to the development of age-related OA-like changes | [98] |
miRNA | miR-141/200c | SIRT1; IL-6/STAT3 | miR-141/200cfl/fl; Col2a1-CreERT2 | Increased retention of NPs inside joint space in cKO mice | [189] |