ncRNA type | ncRNA name | Target genes and pathways | Transgenic mice | Function | Ref |
---|---|---|---|---|---|
miRNA | miR-21 | Spry1 and PDCD4 | miR-21-/- | miR-21 deficiency inhibited bone resorption and osteoclast function | [173] |
miRNA | miR-128 | SIRT1/NF-κB signaling | miR-128 fl/fl; LysM-Cre | Osteoclastic deletion of miR-128 suppressed osteoclastogenesis and exerted a protective effect against bone loss | [174] |
miRNA | miR-143/145 | Cd226 and Srgap2 | miR-143/145-/- | miR-143/145 were shuttled into osteoclasts in extracellular vesicles and triggered osteoclastic activity | [169] |
miRNA | miR-146a | RANKL/OPG signaling | miR-146a-/- | OC activities were impaired in the miR-146a KO mice exposed to estrogen deficiency | [123] |
miRNA | miR-148a | NRP1 | miR-148a-/- | miR-148a KO protects mice against excessive bone resorption | [175] |
miRNA | miR-301b | CYLD/NF-κB signaling | miR-301-bfl/fl; LysM-Cre | Osteoclastic miR-301-b ablation inhibited OVX-induced osteoclastogenesis | [176] |
lncRNA | Nron | CUL4B/Erα signaling | Nronfl/fl; Ctsk-Cre | Nron knockout mice exhibit an osteopenia phenotype with elevated bone resorption activity | [177] |