ncRNA type | ncRNA name | Target genes and pathways | Transgenic mice | Function | Ref |
---|---|---|---|---|---|
miRNA | miR-143 | HDAC7 | miR-143-/- | Promoting angiogenesis coupling with osteoblast differentiation | [163] |
miRNA | miR-143/145 | Sox2 | miR-143/145-/- | miR-143/145 overexpression impaired BMSCs self-renewing and osteoblastic differentiation function | [169] |
miRNA | miR-146a | n.a | MiR-146a-/- | miR-146a inhibited the proliferation and osteoblast differentiation but accelerated apoptosis of MSC | [123] |
miRNA | miR-146a-5p | Sirt1 | miR-146a-/- | miR-146a-5p inhibited the osteoblast differentiation of BMSCs; miR-146a-5p deletion protected female mice from age-induced bone loss | [122] |
miRNA | miR-185 | Bgn/BMP/Smad signaling | miR-185-/- | Redundant bone formation after miR-185 depletion | [170] |
miRNA | miR-188 | HDAC9 and RICTOR | miR-188–/–, osterix + miR-188-Tg mice | Inhibition of miR-188 increased bone formation and decreased bone marrow fat accumulation in aged mice | [167] |
miRNA | miR-338 | Runx2/Sox4/miR-338 signaling | miR-338-/- | Deletion of the miR-338 cluster or injection of a miR-338 cluster inhibitor prevented osteoporosis after ovariectomy | [171] |
miRNA | miR-451a | Bmp6/SMAD1/5/8 | miR-451a-/- | Osteoblasts and MSCs isolated from miR-451a KO mice showed promoted osteogenesis | [172] |
miRNA | miR-497 ~ 195 cluster | Notch and HIF-1a | miR-497 ~ 195 fl/fl; Cdh5 (PAC)-Cre | Promoting angiogenesis coupled with osteogenesis; target for age-related osteoporosis | [164] |
LncRNA | Bmncr | FMOD; TAZ RUNX2/PPARG interation | Bmncr-/- | Restoring BMNCR levels in human BMSCs reversed the age-related switch between osteoblast and adipocyte differentiation | [165] |
LncRNA | Crnde | Wnt/β-catenin signaling | Crnde-/- | Crnde knockout impaired osteoblast proliferation and differentiation | [166] |
LncRNA | Neat1 | Smurf1/Runx2 | Neat1-/- | Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation | [168] |