Galectin | Model | Strategy | EMT Marker | Signaling Pathway | Ref |
---|---|---|---|---|---|
Gal-1 | CAFs derived from gastric cancer patients, gastric cancer cell lines (MGC-803) | CAF secreted, overexpression and knockdown in CAFs | E-cadherin Vimentin | β1-integrin activation | [158] |
Gastric cancer cell line (MGC-803) | Overexpression, knockdown | N. D | [147] | ||
Gastric cancer cell lines (MGC-803 and SGC-7901) | Overexpression, knockdown, CAF secreted | TGF-β/ Smad | [155] | ||
Overexpression | S1PR1 | [159] | |||
Gastric cancer cell lines (MGC-803 and MKN-74) | Overexpression, knockdown, exogenously added, blockade with lactose | Gli-1 | [157] | ||
Ovarian cancer cell lines (SK-OV-3 and SK-OV-3-ip) | Overexpression, knockdown | E-cadherin N-cadherin, vimentin, MMP-7, fibronectin, Snail, Slug | MAPK JNK/p38 | [146] | |
Ovarian cancer cell line (SK-OV-3) | Secretion stimulation with LPS, knockdown | E-cadherin MMP-2, MMP-9, N-cadherin, vimentin, α-SMA, Snail, Slug | TLR4 activation/ PI3K/AKT | [166] | |
Colorectal cancer cell lines (HCT116, HCT8 and HT29) | Secretion stimulation with LPS, exogenously added, knockdown | E-cadherin Snail, vimentin, α-SMA, ZEB1, N-cadherin, MMP-2, MMP-9 | TLR4/ERK | [167] | |
Colorectal cancer cell line (KM12C), fibroblasts cell lines (MRC-5 and WS1) | Knockdown, CAFs secreted, exogenously added | E-cadherin, Twist1, Slug | 𝛽-catenin | [171] | |
HCC cell lines (Huh7, Hep3B, HCCLM3 and MHCC97H) | Overexpression, knockdown | E-cadherin N-cadherin, vimentin | α5β3-integrin FAK/ PI3K/AKT | [127] | |
HCC cell line (HepG2) | Overexpression, knockdown | E-cadherin, ZO-1 Vimentin, Snail | PI3K/AKT/ 𝛽-catenin | [148] | |
Upper urothelial carcinoma cell lines (BFTC-909, T24 and J 82) | Exogenously added, knockdown | E-cadherin, ZO-1 Snail, vimentin, N-cadherin, β-catenin, MMP-2, MMP-9 | FAK/PI3K/AKT | [168] | |
Pancreatic ductal adenocarcinoma cell lines (PanC-1) | Overexpression, knockdown, secreted from stromal pancreatic stellate cells | E-cadherin Vimentin, Twist, MMP-9 | NF-κB | [170] |