Galectin | Model | Strategy | EMT phenotype | Signaling pathway | Ref |
---|---|---|---|---|---|
Gal-2 and Gal- 4 | Intestinal epithelium cells | Exogenously added, blockade with lactose | Increased wound closure and proliferation | TGF-β | [103] |
Gal-3 | Cornea cells from mice | Deletion in mice, exogenously added, blockade with lactose | Increased wound closure | N.D | [105] |
Colon epithelium cells | Exogenously added, blockade with lactose | Increased wound closure | N.D | [113] | |
Mice epidermis and cells | Deletion in mice | Increased cell migration | EGFR/ERK | [108] | |
Immortalized keratinocytes and keratinocytes isolated from patients | Exogenously added, blockade with lactose | Weakening of cell-cell adhesion and increased cell migration | β4 integrin/laminin332/EGFR | [111] | |
Human corneal keratinocytes and mice | Deletion in mice, exogenously added, blockade with lactose | Occludin mislocalization, weakening of cell-cell adhesion, reorganization of the actin cytoskeleton, MMP-9 secretion, and cell detachment | CD147 | [112] | |
Gal-7 | Mice | Deletion in mice | E-cadherin/ β -catenin mislocalization, increased proliferation, decreased cell migration | N.D | [116] |
Mice and keratinocyte cell lines | Overexpression in mice epidermis | Decreased E-cadherin, weakening of cell-cell adhesion | N.D | [117] | |
Epidermal cells | Knockdown, exogenously added, blockade with lactose | Cell polarity, wound closure, E-cadherin on cell surface | N.D | [118] |